Electron transfer (ET) reactions represent a widespread and exciting research field in chemistry as well as in biology and physics. In particular, the biomacromolecule DNA as an interesting functional -system for molecular electronics and a unique medium for electron transfer has attracted a considerable amount of research efforts. In principle, DNA-mediated charge transfer processes can be categorized as oxidative hole transfer and reductive electron transfer. We focused our work on the spectroscopic and chemical investigation of reductive electron transfer. New photochemical assays consisting of fluorophore-modified oligonucleotides have been synthesized and developed which give new insights into the mechanism of these processes. Currently, an electron hopping mechanism is proposed which involves pyrimidine radical anions as intermediate electron carriers.
Reviews:
[1] H.-A. Wagenknecht (Ed.), Charge Transfer in DNA, Wiley-VCH, Weinheim, 2005.
[2] H.-A. Wagenknecht, Nat. Prod. Rep. 2006, 23, 973-1006.
[3] H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2006, 45, 5583-5585.
[4] H.-A. Wagenknecht, Curr. Org. Chem. 2004, 8, 251-266.
[5] H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2003, 42, 3204-3206.
[6] H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2003, 42, 2454-2460. Research papers:
[3] L. Valis, Q. Wang, M. Raytchev, I. Buchvarov, H.-A. Wagenknecht, T. Fiebig, Proc. Natl. Acad. Sci. 2006, 103, 10192-10195.
[4] C. Wagner, H.-A. Wagenknecht, Org. Lett. 2006, 8, 4191-4194.
[5] C. Wanninger, H.-A. Wagenknecht, Synlett 2006, 2051-2054.
[6] J. Barbaric, H.-A. Wagenknecht, Org. Biomol. Chem. 2006, 4, 2088-2090.
[6] L. Valis, E. Mayer-Enthart, H.-A. Wagenknecht, Bioorg. Med. Chem. Lett. 2006, 16, 3184-3187.
[7] E. Mayer-Enthart, H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2006, 45, 3372-3375.
[8] L. Valis, N. Amann, H.-A. Wagenknecht, Org. Biomol. Chem 2005, 3, 36-38.
Electron transfer (ET) reactions represent a widespread and exciting research field in chemistry as well as in biology and physics. In particular, the biomacromolecule DNA as an interesting functional -system for molecular electronics and a unique medium for electron transfer has attracted a considerable amount of research efforts. In principle, DNA-mediated charge transfer processes can be categorized as oxidative hole transfer and reductive electron transfer. We focused our work on the spectroscopic and chemical investigation of reductive electron transfer. New photochemical assays consisting of fluorophore-modified oligonucleotides have been synthesized and developed which give new insights into the mechanism of these processes. Currently, an electron hopping mechanism is proposed which involves pyrimidine radical anions as intermediate electron carriers.
Reviews:
[1] H.-A. Wagenknecht (Ed.), Charge Transfer in DNA, Wiley-VCH, Weinheim, 2005.
[2] H.-A. Wagenknecht, Nat. Prod. Rep. 2006, 23, 973-1006.
[3] H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2006, 45, 5583-5585.
[4] H.-A. Wagenknecht, Curr. Org. Chem. 2004, 8, 251-266.
[5] H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2003, 42, 3204-3206.
[6] H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2003, 42, 2454-2460. Research papers:
[3] L. Valis, Q. Wang, M. Raytchev, I. Buchvarov, H.-A. Wagenknecht, T. Fiebig, Proc. Natl. Acad. Sci. 2006, 103, 10192-10195.
[4] C. Wagner, H.-A. Wagenknecht, Org. Lett. 2006, 8, 4191-4194.
[5] C. Wanninger, H.-A. Wagenknecht, Synlett 2006, 2051-2054.
[6] J. Barbaric, H.-A. Wagenknecht, Org. Biomol. Chem. 2006, 4, 2088-2090.
[6] L. Valis, E. Mayer-Enthart, H.-A. Wagenknecht, Bioorg. Med. Chem. Lett. 2006, 16, 3184-3187.
[7] E. Mayer-Enthart, H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2006, 45, 3372-3375.
[8] L. Valis, N. Amann, H.-A. Wagenknecht, Org. Biomol. Chem 2005, 3, 36-38.
