Progress toward and modeling of a minimally invasive penta-analyte biochip system, the Physiological Status Monitoring (PSM) BioChip™, designed for monitoring key biomarkers of physiological stress during hemorrhagic trauma and vascular allograft transplantation is presented. Intended to allow for patient stratification/segmentation, individual biomedical and biosensor elements employ nano-enabled Sensing, Measuring, and Actively Responding Technical (SMART) hydrogels that may be electroconductive and bioactive. In each case, molecular engineering of the ABIO-BIO (solid-to-soft) interface improves adhesion, analytical reproducibility, and functional device performance. These examples serve to showcase how convergence in research, particularly at C3B®, leads to the development of innovative solutions with applications in healthcare, biotechnology, and related fields. The collaborative efforts of researchers from diverse disciplines contribute to a more comprehensive and impactful approach to addressing complex challenges.
1. Aggas, J. R. et al. Real-Time Monitoring Using Multiplexed Multi-Electrode Bioelectrical Impedance Spectroscopy for the Stratification of Vascularized Composite Allografts: A Perspective on Predictive Analytics. Bioengineering 10, 434 (2023).
2. Abasi, S., Jain, A., Cooke, J. P. & Guiseppi-Elie, A. Electrically stimulated gene expression under exogenously applied electric fields. Frontiers in Molecular Biosciences 10, doi:10.3389/fmolb.2023.1161191 (2023).
Prof. Dr. Anthony (Tony) Guiseppi-Elie is an international medical sciences, engineering, and innovation consultant at the American International Institute of Medical Sciences, Engineering and Innovation, an academic consultancy and think tank focused on convergence in education. He has 15 years of experience in industrial research and product development, at large and startup companies, and 18 years of experience as a tenured, titled, and endowed full professor, department head, associate dean, dean, and vice president at universities that include Virginia Commonwealth University (VCU), Clemson University (Clemson), Texas A&M University (TAMU), and Anderson University (AU). His appointments have been in Chemical and Biomolecular Engineering, Bioengineering, and Electrical and Computer Engineering. At TAMU he held the TEES Research Professorship in Engineering and served as the founding associate dean of engineering innovation in the college of engineering where he co-founded the convergent School of Engineering-Medicine. At AU founded a unique, industry-supported, convergent liberal-arts engineering curriculum. A US citizen who was born in Trinidad and Tobago, he holds the Sc.D. in Materials Science and Engineering from MIT, the M.Sc. in Chemical Engineering from the University of Manchester (UMIST), and the B.Sc. (First Class Honors) in Applied, Analytical, and Biochemistry from the University of the West Indies (UWI). He has published over 225 peer-reviewed journal articles, holds 8 patents, and is a fellow of IEEE, AIMBE, BMES, The RSC and The RSM. His research interests are in physiological status monitoring during hemorrhagic trauma and allotransplantation, polymeric nanobiomaterials in drug delivery and tissue regeneration, and fully integrated microanalytical systems in the service of human health and medicine. (GS02.2024|h-index=51|>9,600 citations).
Progress toward and modeling of a minimally invasive penta-analyte biochip system, the Physiological Status Monitoring (PSM) BioChip™, designed for monitoring key biomarkers of physiological stress during hemorrhagic trauma and vascular allograft transplantation is presented. Intended to allow for patient stratification/segmentation, individual biomedical and biosensor elements employ nano-enabled Sensing, Measuring, and Actively Responding Technical (SMART) hydrogels that may be electroconductive and bioactive. In each case, molecular engineering of the ABIO-BIO (solid-to-soft) interface improves adhesion, analytical reproducibility, and functional device performance. These examples serve to showcase how convergence in research, particularly at C3B®, leads to the development of innovative solutions with applications in healthcare, biotechnology, and related fields. The collaborative efforts of researchers from diverse disciplines contribute to a more comprehensive and impactful approach to addressing complex challenges.
1. Aggas, J. R. et al. Real-Time Monitoring Using Multiplexed Multi-Electrode Bioelectrical Impedance Spectroscopy for the Stratification of Vascularized Composite Allografts: A Perspective on Predictive Analytics. Bioengineering 10, 434 (2023).
2. Abasi, S., Jain, A., Cooke, J. P. & Guiseppi-Elie, A. Electrically stimulated gene expression under exogenously applied electric fields. Frontiers in Molecular Biosciences 10, doi:10.3389/fmolb.2023.1161191 (2023).
Prof. Dr. Anthony (Tony) Guiseppi-Elie is an international medical sciences, engineering, and innovation consultant at the American International Institute of Medical Sciences, Engineering and Innovation, an academic consultancy and think tank focused on convergence in education. He has 15 years of experience in industrial research and product development, at large and startup companies, and 18 years of experience as a tenured, titled, and endowed full professor, department head, associate dean, dean, and vice president at universities that include Virginia Commonwealth University (VCU), Clemson University (Clemson), Texas A&M University (TAMU), and Anderson University (AU). His appointments have been in Chemical and Biomolecular Engineering, Bioengineering, and Electrical and Computer Engineering. At TAMU he held the TEES Research Professorship in Engineering and served as the founding associate dean of engineering innovation in the college of engineering where he co-founded the convergent School of Engineering-Medicine. At AU founded a unique, industry-supported, convergent liberal-arts engineering curriculum. A US citizen who was born in Trinidad and Tobago, he holds the Sc.D. in Materials Science and Engineering from MIT, the M.Sc. in Chemical Engineering from the University of Manchester (UMIST), and the B.Sc. (First Class Honors) in Applied, Analytical, and Biochemistry from the University of the West Indies (UWI). He has published over 225 peer-reviewed journal articles, holds 8 patents, and is a fellow of IEEE, AIMBE, BMES, The RSC and The RSM. His research interests are in physiological status monitoring during hemorrhagic trauma and allotransplantation, polymeric nanobiomaterials in drug delivery and tissue regeneration, and fully integrated microanalytical systems in the service of human health and medicine. (GS02.2024|h-index=51|>9,600 citations).
